Founded by Rene Clusel in 1969, the winery is now run by his son, Gilbert. In 1989 the domaine changed its name to Domaine Clusel-Roch, borrowing the name of Gilbert's wife, Brigitte Roch, and giving the newer, larger winery its own identity.
Today the property is still tiny: just 3.5 hectares in Cote Rotie and just half a hectare in Condrieu. The vines are planted on terraces along the Cote Rotie, with two wooden stakes tied above each vine to help protect against the region's occasionally howling winds. Having officially converted to organic farming practices in 2002, most work in the vineyards is done manually, without the use of any chemical fertilizers.